circRNAs对哺乳动物胎盘养分转运和胎儿发育的影响

doi:10.11843/j.issn.0366-6964.2019.10.001

畜牧兽医学报 ›› 2019, Vol. 50 ›› Issue (10): 1955-1962.doi: 10.11843/j.issn.0366-6964.2019.10.001

circRNAs对哺乳动物胎盘养分转运和胎儿发育的影响

何天乐^1,2, 董国忠^1,2, 杨震国^1,2*

1. 西南大学动物科技学院生物饲料与分子营养实验室, 重庆 400715;
2. 重庆市牧草与草食家畜重点实验室, 重庆市草食动物资源保护与利用工程技术研究中心, 重庆市高校草食动物工程研究中心, 重庆 400715

收稿日期:2019-03-21 出版日期:2019-10-23 发布日期:2019-10-23
通讯作者: 杨震国,主要从事母体营养与繁殖生理的相关研究,E-mail:guoguo00002@163.com
作者简介:何天乐(1994-),男,甘肃庆城人,硕士,主要从事母体营养与繁殖生理的相关研究,E-mail:1971763109@qq.com
基金资助:
国家重点研发计划课题（2018YFD0501004）；重庆市自然科学基金（基础研究与前沿探索专项）面上项目（cstc2019jcyj-msxmX0524）；西南大学博士启动基金项目（SWU117043）；2018中国博士后科学基金第64批面上项目（2018M640895）；2018年重庆市博士后科研项目特别资助（XmT2018061）；重庆高校创新团队建设计划项目（CXTDG201602004）

Regulation of circRNAs on Mammalian Placental Nutrient Transport and Fetal Development

HE Tianle^1,2, DONG Guozhong^1,2, YANG Zhenguo^1,2*

1. Laboratory for Bio-feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, China;
2. Chongqing Key Laboratory of Forage & Herbivore, Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization, Chongqing Herbivore Engineering Research Center, Chongqing 400715, China

Received:2019-03-21 Online:2019-10-23 Published:2019-10-23

摘要/Abstract

摘要： circRNAs是一类具有闭合环状结构的内源非编码RNA分子。近几年的研究发现，circRNAs在真核生物中普遍存在，它不但有一定的保守性和细胞特异性，而且还具有调控基因转录的作用。胎盘养分转运对胎儿发育非常重要，甚至决定了胎儿能否顺利产出，对日后生长发育状况也有很大影响。猪和鼠上的研究均表明，circRNAs在胎盘养分转运和胎儿发育过程中具有重要的调控作用。本文综述了circRNAs的来源、产生机制、分类、特点及其功能，并结合动物生产实际情况综述了circRNAs对哺乳动物胎盘中葡萄糖、氨基酸、脂肪酸等养分转运及胎儿发育的调控作用。

Abstract: circRNAs are a subclass of endogenous non-coding RNAs with a closed continuous loop. In recent years, lots of studies have found that circRNAs are ubiquitous in eukaryotes. They not only have certain conserved characteristics and cell specificity, but also play a regulatory role in gene transcription. Regulation of nutrient transport across the placenta is very important for the fetal development, which even determines whether the fetus could be successfully delivered and also affects its future growth and development. Studies in pigs and mice have shown that circRNAs play an important regulatory role in placental nutrient transport and fetal development. This paper reviews the sources, production mechanisms, classification, characteristics and functions of circRNAs. Combined with animal production, the regulation role of circRNAs on nutrient transport of glucose, amino acids and fatty acids in mammalian placenta and fetal development are also reviewed.

中图分类号:

S811.4

何天乐, 董国忠, 杨震国. circRNAs对哺乳动物胎盘养分转运和胎儿发育的影响[J]. 畜牧兽医学报, 2019, 50(10): 1955-1962.

HE Tianle, DONG Guozhong, YANG Zhenguo. Regulation of circRNAs on Mammalian Placental Nutrient Transport and Fetal Development[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(10): 1955-1962.

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circRNAs对哺乳动物胎盘养分转运和胎儿发育的影响

Regulation of circRNAs on Mammalian Placental Nutrient Transport and Fetal Development

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